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Tocris Bioscience™ BC-LI-0186

Catalog No. 679125
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5 mg
25 mg
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679125 25 mg
67915 5 mg
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Catalog No. 679125 Supplier Tocris Bioscience™ Supplier No. 6791/25
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Description

Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor

BC-LI-0186 is a potent and high affinity leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor (IC50 = 46.1 nM; Kd = 42.1 nM for binding to LRS). Inhibits mTOR complex 1 activity by blocking binding to LRS without affecting catalytic activity. Inhibits leucine-induced translocation of LRS to the lysosome.

Specifications

Chemical Name or Material 4-[2,5-Dihydro-2,3-dimethyl-4-(1-methylethyl)-5-oxo-1 H-pyrazol-1-yl]-N-(2-phenoxyethyl)benzenesulfonamide
CAS 695207-56-8
Quantity 25 mg
Target Ras GTPase Inhibitors
Molecular Formula C22H27N3O4S
Formula Weight 3939
Purity 98%