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Tocris Bioscience™ BAY 1797

Catalog No. 757350
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50 mg
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757350 50 mg
757310 10 mg
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Catalog No. 757350 Supplier Tocris Bioscience™ Supplier No. 7573/50
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Description

Selective P2X4 antagonist

BAY 1797 is a selective purinergic P2X4 receptor antagonist (IC50 values are 108, 112 and 233 nM for the human, mouse and rat P2X4, respectively). It is selective for P2X4 over P2X3, P2X7, and P2X1 receptors (IC50 values are 8.3, 10.6 and >50 μM, respectively, for the human receptors). BAY 1797 dose-dependently reduces prostaglandin E2 levels and exhibits anti-inflammatory and analgesic effects in an in vivo model of inflammatory pain. Orally active.

Specifications

Chemical Name or Material N-[3-(Aminosulfonyl)-4-(3-chlorophenoxy)phenyl]benzeneacetamide
CAS 2055602-83-8
Quantity 50 mg
Target P2X4
Molecular Formula C20H17ClN2O4S