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Tocris Bioscience™ AZ 12799734

Catalog No. 687010
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50 mg
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Catalog No. Quantity
687010 10 mg
687050 50 mg
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Catalog No. 687010 Supplier Tocris Bioscience™ Supplier No. 6870/10

Description

Potent TGF-βRI inhibitor

AZ 12799734 is a potent inhibitor of transforming growth factor-β type I receptor (TGF-βRI; ALK5) (IC50 = 17 nM in cellular inhibition assay and 47 nM in TGF-β-induced luciferase activity assay). Also inhibits ALK4, ALK6 and ALK7 at concentrations under 10 μM. Inhibits BMP signaling, phosphorylation of SMAD1 and SMAD2, and TGF-β-induced epithelial cell migration in vitro. Displays cardiotoxicity in vivo. Orally bioavailable.

Specifications

Chemical Name or Material 4-[[4-[(2.6-Dimethyl-3-pyridinyl)oxy]-2-pyridinyl]amino]benzenesulfonamide
CAS 1117684-36-2
Quantity 10 mg
Molecular Formula C18H18N4O3S
Purity 98%