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Tocris Bioscience™ Axitinib

Catalog No. 435050
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50 mg
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Catalog No. Quantity
435050 50 mg
435010 10 mg
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Catalog No. 435050 Supplier Tocris Bioscience™ Supplier No. 4350/50*

Description

Potent VEGFR-1, -2 and -3 inhibitor

Axitinib is a potent inhibitor of VEGFR-2, -3, and -1 (IC50 values are 0.2, 0.1-0.3, and 1.2 nM respectively). Axitinib exhibits minimal activity against a panel of ∼100 protein kinases. Axitinib inhibits angiogenesis and vascular permeability. Also a high affinity BCR-ABL1 (T315I) inhibitor (Ki = 149 pM for autophosphorylated ABL1 (T315I)). Axitinib blocks proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Axitinib (10 mg/kg) decreases T-cell exhaustion and tumor and T-cell hypoxia and improves survival in mice in vivo. Orally available.

Chemical Identifiers

CAS 319460-85-0
Molecular Formula C22H18N4OS

Specifications

Quantity 50 mg
Formula Weight 386.47
Purity >99%
Molecular Weight (g/mol) 386.473
Chemical Name or Material Axitinib

Safety and Handling

Recommended Storage Store at +4°C