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Tocris Bioscience™ A 1331852

Catalog No. 766110
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766110 10 mg
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Catalog No. 766110 Supplier Tocris Bioscience™ Supplier No. 7661/10
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Description

Potent and selective Bcl-xL inhibitor; antitumor and inducer of apoptosis

A 1331852 is a high affinity and selective Bcl-xL inhibitor (Ki <0.01 nM), also inhibits Bcl-W, Bcl-2, and Mcl-1 (Ki values are 4, 6 and 142 nM, respectively). A 1331852 inhibits Bcl-xL-dependent Molt 4 acute lymphoblastic leukemia cell growth in vitro (EC50 = 6 nM). It enhances antitumor effects of Docetaxel (Cat. No. 4056) and Venetoclax (Cat. No. 6960) in xenograft models of breast and lung cancer. A 1331852 also induces apoptosis in and clears senescent biliary epithelial cells (BECs), and induces apoptosis in xenograft models of EBV-associated T- and natural killer cell lymphoma.

Specifications

Chemical Name or Material 6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1 H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7 ]dec-1-ylmethyl)-1 H-pyrazol-4-yl]-2-pyridinecarboxylic acid
CAS 1430844-80-6
Quantity 10 mg
Target Bcl-xL
Molecular Formula C38H38N6O3S
Purity 0.98