Applied Biosystems Capillary Electrophoresis Genetic Analyzers and Consumables

Sanger sequencing is used to study a small subset of genes linked to a defined phenotype, confirm next-generation sequencing (NGS) variants, detect minor allele fractions down to 5%, or read contiguous sequences up to 1,000 bases.

Fragment analysis is a powerful technique with simple, straightforward workflows. It’s used in a range of applications such as detection of mutations, genotyping, identification of short tandem repeats, and gene expression profiling.

Applied Biosystems™ genetic analysis systems and consumables such as Applied Biosystems™ Big Dye™ products, POP polymers, and clean-up products are trusted standards for Sanger sequencing and fragment analysis by capillary electrophoresis. They’re proven through decades of results, including the first sequencing of the human genome and the discovery of genes implicated in diseases like cystic fibrosis.

Resources

SeqStudio Flex Series Genetic Analyzers Application Guide (PDF, 9.3 MB) MLPA Assays on the SeqStudio Genetic Analyzer (PDF, 2.1 MB) 16S Direct Workflow (PDF, 884 KB) Detecting Mutations with Extended RAS Research Assays (PDF, 1 MB) Authenticating Human Cell Lines (PDF, 2.1 MB) Performing Sanger Sequencing and Fragment Analysis (PDF, 2 MB)

Applied Biosystems SeqStudio Flex Genetic Analyzer Tour

See how features such as an integrated touchscreen, intuitive software, continuous plate loading, and more deliver performance and flexibility.

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Capillary Electrophoresis Applications

Plasmid Sequencing

Accurately analyze subcloned inserts with read lengths ranging from <300 bp to >600 bp.

Species Identification

Identify bacterial 16s rRNA with access to the groundbreaking phylogenetic research work of Carl Woese et al.

CRISPR-Cas9 Gene Editing

Evaluate the efficiency of CRISPR events, quantify gene editing activity (target region analyzed using TIDE software), characterize the gene target in cell lines, assess gene copy number, and more.

Cell Line Authentication (CLA)

Confidently detect contaminating cell lines with sensitivity and accuracy.

SNP Genotyping

The Applied Biosystems™ SNaPshot™ Multiplex System saves time with built-in reporting of fragment analysis and by combining sequencing and fragment analysis on the same plate during the same run.

MLPA

Analyze human copy number variation (CNV) with Multiplex Ligation-Dependent Probe Amplification (MLPA™).

Oncology Research

Confirm next-generation sequencing.

"The SeqStudio instrument was very easy to set up in the lab; it did not require us to have a lot of initial expertise because the instrument is extremely easy to handle. By using the RAS panel, we found very consistent results across the different platforms that we used, whether it was the Sanger platform or the NGS platform."

Dr. Luca Quagliata, Senior Director of the Contract R&D Unit at the Institute of Medical Genetics and Pathology, University Hospital of Basel, Switzerland

Behind the Bench Blog

Find news and articles about SeqStudio Genetic Analyzers and much more.

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SeqStudio System and Accessories

The Applied Biosystems SeqStudio Genetic Analyzer is a four-capillary, fluorescence-based electrophoresis system designed to provide an integrated genetic analysis research experience that is easy, efficient, and versatile.

Sequencing and Clean-Up Kits

The Applied Biosystems™ Sanger Sequencing Kit includes all the reagents needed to clean up PCR and sequencing products and perform cycle sequencing: Applied Biosystems™ ExoSAP-IT™ Express Reagent, a BigDye™ Terminator Cycle Sequencing Kit, and a BigDye XTerminator™ Purification Kit. The simple, fast workflow helps you complete Sanger sequencing — from sample to answer — in less than one workday.