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ZAP-70 Monoclonal Antibody (1E7.2), Alexa Fluor™ 647, eBioscience™, Invitrogen™ 
Mouse Monoclonal Antibody
$530.00 - $530.00
Specifications
| Antigen | ZAP-70 |
|---|---|
| Clone | 1E7.2 |
| Concentration | 0.2 mg/mL |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
Description
Mouse Monoclonal Antibody
ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins. ZAP-70 is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.Specifications
| ZAP-70 | |
| 0.2 mg/mL | |
| Monoclonal | |
| Liquid | |
| RUO | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| 22637, 7535 | |
| IgG1 κ | |
| Affinity chromatography | |
| Antibody |
| 1E7.2 | |
| Flow Cytometry | |
| Alexa Fluor 647 | |
| Mouse | |
| Human, Mouse | |
| P43403, P43404 | |
| ZAP70 | |
| Primary | |
| 4°C, store in dark, DO NOT FREEZE! | |
| ZAP70 |