Invitrogen™ VASN Polyclonal Antibody

Description

Immunogen sequence: LDVSNLSLQA LPGDLSGLFP RLRLLAAARN PFNCVCPLSW FGPWVRESHV TLASPEETRC HFPPKNAGRL LLELDYADFG CPATTTTATV PTTRPVVREP TALSSSLAPT Highest antigen sequence indentity to the following orthologs: Mouse - 86%, Rat - 90%.

The VASN gene encodes the protein vasorin, a type I transmembrane protein involved in cellular signaling, vascular development, and tissue repair. Vasorin is characterized by its expression in various tissues, including vascular endothelial cells and smooth muscle cells, where it functions to modulate cell proliferation and differentiation. It plays a significant role in the regulation of vascular remodeling and homeostasis by interacting with signaling molecules like transforming growth factor-beta (TGF-β), thereby influencing processes such as angiogenesis and wound healing. Vasorin is implicated in inhibiting TGF-β signaling pathways, which are crucial for maintaining vascular integrity and preventing excessive fibrosis during tissue repair. Dysregulation of VASN expression can contribute to pathological conditions, including cardiovascular diseases and cancer, where abnormal vascular remodeling and cell proliferation are evident. Research into vasorin continues to explore its functional mechanisms and potential therapeutic applications in diseases characterized by vascular dysregulation and tissue remodeling.