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  6. Invitrogen™ Ubiquitin Monoclonal Antibody (eBioP4D1 (P4D1)), eBioscience™, Invitrogen™

Invitrogen™ Ubiquitin Monoclonal Antibody (eBioP4D1 (P4D1)), eBioscience™, Invitrogen™

Catalog No. 14607837
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14607837 2 mg
14607895 10 mg
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Catalog No. 14607837 Supplier Invitrogen™ Supplier No. 14607837
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Description

Mouse Monoclonal Antibody

Description: The monoclonal antibody eBioP4D1 (p4D1) recognizes ubiquitin, a small 8Ka protein. Ubiquitin units are linked to proteins via a ubiquitination process, thereby signaling the protein for degradation by the 26S proteosome. The process of ubiquitination plays a role in differentiation, cell cycle progression, apoptosis and disease progression. For example, neuronal inclusions called Lewis bodies from Parkinson patients are rich in ubiquitin. Applications Reported: This eBioP4D1 (P4D1) antibody has been reported for use in immunoprecipitation, immunoblotting (WB), and immunohistochemical staining. Applications Tested: This eBioP4D1 (P4D1) antibody has been tested by immunblotting of treated cell lines. This can be used at less than or equal to 2 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.

Specifications

Antigen Ubiquitin
Applications Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone eBioP4D1 (P4D1)
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene UBB
Gene Accession No. P0CG47, P0CG48, P0CG49, P0CG50, P0CG51, P24051, P62979, P62982, P62983, P62984, P62986, P62987, Q63429, Q6ZWY3, Q71UM5
Gene Alias 0610006J14Rik; 1810034D23Rik; 2700054O04Rik; 40S ribosomal protein S27a; 40S ribosomal protein S27-like; 40S ribosomal protein S27-like protein; AI194771; AL033289; CEP80; CG5271; CG5271-PA; Chap1; Dmel\CG5271; Dmel_CG5271; Dub80; epididymis luminal protein 112; epididymis secretory protein Li 50; HEL112; HEL-S-50; hm:zeh0386; HMG20; hPLIC-2; HRIHFB2157; HUBCEP52; ik:tdsubc_1f2; l(2)04820; l(2)31Ei; LOC100912032; LOC101747587; male female sterile 31; mfs(2)31; mfs(2)48; mfs48; OTTHUMP00000200786; OTTHUMP00000201692; PLIC-2; polyubiquitin; polyubiquitin B; polyubiquitin C; poly-ubiquitin precursor; polyubiquitin-B; Polyubiquitin-C; polyubiquitin-C-like; RE44350p; ribosomal protein S27; ribosomal protein S27 like; ribosomal protein S27A; ribosomal protein S27a L homeolog; ribosomal protein S27a S homeolog; ribosomal protein S27-like; ribosomal protein S27-like protein; RPL40; RpS27; Rps27a; rps27a.L; rps27a.S; RpS27A-PA; RPS27L; S27A; similar to polyubiquitin; similar to ubiquitin-S27a fusion protein; Small ribosomal subunit protein eS27-like; Small ribosomal subunit protein eS31; tdsubc_1f2; TI-225; UB3-D; Uba52; UBA80; UBB; Ubb2; UBC; UBCEP1; UBCEP80; Ubi-f80; Ubi-m; Ubiq; Ubiquilin 2; ubiquitin; ubiquitin (34 AA) (1 is 2nd base in codon); ubiquitin and ribosomal protein S27a; ubiquitin B; ubiquitin C; ubiquitin carboxyl extension protein 80; ubiquitin copy 4; ubiquitin fusion 80; ubiquitin polyprotein (heat shock related); ubiquitin/ribosomal protein; ubiquitin-40S ribosomal protein S27a; ubiquitin-40S ribosomal protein S27a-like; ubiquitin-CEP80; ubiquitin-hybrid protein precursor; Ubiquitin-monomeric; Ubiquitin-related; Ubiquitin-related 1; Ubiquitin-related 2; ubiquitin-S27a fusion protein; Unknown (protein for MGC:127652); unnamed protein product; XELAEV_18028796mg; xx:tdsubc_1f2; zgc:66168; zgc:66168 protein
Gene Symbols RPS27A, RPS27L, UBA52, UBB, UBC
Host Species Mouse
Purification Method Affinity chromatography
Quantity 2 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100912032, 192255, 22186, 22187, 22190, 50522, 51065, 6233, 64156, 67941, 681429, 7311, 7314, 7316, 78294
Target Species Human, Mouse, Rat, All species
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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