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Tyrphostin A23, 99%, Thermo Scientific Chemicals
Description
Tyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Tyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.
Solubility
Soluble in DMSO, ethanol, or DMF
Notes
Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, acids, heat.
Specifications
Specifications
| Color | Brown to Yellow |
| Quantity | 5 mg |
| Solubility Information | Soluble in DMSO, ethanol, or DMF |
| Formula Weight | 186.17 |
| Percent Purity | 99% |
| Physical Form | Powder |
| Chemical Name or Material | Tyrphostin A23 |
Safety and Handling
| TSCA | No |
| Recommended Storage | Store at -20°C |
RUO – Research Use Only