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  8. Tolfenamic acid, 99+%

Tolfenamic acid, 99+%

Numéro de catalogue. AAJ6125609
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Numéro de catalogue. AAJ6125609 Fournisseur Thermo Scientific Chemicals Code fournisseur J6125609
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Description

NSAID that activates calcium-activated potassium channels | CAS: 13710-19-5 | C14H12ClNO2 | 261.705 g/mol

Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 μM.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 µM.

Solubility
Soluble in water (slightly), acetone (∼10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (∼10 mg/ml) and ethanol (50 mg/ml).

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.

Identifiants chimiques

CAS 13710-19-5
Molecular Formula C14H12ClNO2
Molecular Weight (g/mol) 261.705
MDL Number MFCD00133865
InChI Key YEZNLOUZAIOMLT-UHFFFAOYSA-N
Synonym tolfenamic acid, clotam, n-3-chloro-2-methylphenyl anthranilic acid, 2-3-chloro-2-methylphenyl amino benzoic acid, tolfedine, acido tolfenamico, acide tolfenamique, acidum tolfenamicum, tolfine, n-2-methyl-3-chlorophenyl anthranilic acid
PubChem CID 610479
ChEBI CHEBI:32243
IUPAC Name 2-(3-chloro-2-methylanilino)benzoic acid
SMILES CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O

Spécifications

Color White
Quantity 10 g
UN Number UN2811
Merck Index 14,9513
Solubility Information Soluble in water (slightly),acetone (∽10mg/ml),DMSO (52mg/ml at 25°C),methanol (∽10mg/ml) and ethanol (50mg/ml).
Formula Weight 261.7
Percent Purity ≥99%
Physical Form Crystalline Powder
Chemical Name or Material Tolfenamic acid

Sécurité et manipulation

Hazard Category H301
Hazard Statement GHS H Statement
H301
Toxic if swallowed.
Precautionary Statement P264b-P270-P301+P310-P330-P501c
DOTInformation Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber 237-264-3
RTECSNumber CB2687500
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only