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Invitrogen™ TNPO3 Polyclonal Antibody
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Catalog No. PIPA520551
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100 μg
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Catalog No. Quantity
PIPA520551 100 μg
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Catalog No. PIPA520551 Supplier Invitrogen™ Supplier No. PA520551
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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat liver tissue lysate. PA5-20551 can be used with blocking peptide PEP-0671.

TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.

Specifications

Antigen TNPO3
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TNPO3
Gene Accession No. Q6P2B1, Q9Y5L0
Gene Alias 5730544L10Rik; C430013M08Rik; C81142; D6Ertd313e; Imp12; importin 12; Importin-12; IPO12; LGMD1F; limb girdle muscular dystrophy 1F (autosomal dominant); mKIAA4133; MTR10A; Tnpo3; transportin 3; transportin-3; Transportin-SR; TRNSR; TRN-SR; TRN-SR2
Gene Symbols TNPO3
Host Species Rabbit
Immunogen An 18 amino acid peptide from near the amino terminus of human TNPO3.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23534, 296954, 320938
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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