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Invitrogen™ TNFRSF14 Chimeric Recombinant Armenian Hamster Monoclonal Antibody (HMHV-1B18)
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Catalog No. MA551650
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200 μg
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Catalog No. Quantity
MA551650 200 μg
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Catalog No. MA551650 Supplier Invitrogen™ Supplier No. MA551650
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Description

Armenian Hamster Recombinant Monoclonal Antibody

This antibody is specific for Herpes Virus Entry Mediator (HVEM, TR2), a type I transmembrane protein of TNF-receptor superfamily. This receptor, which is expressed on most cell types, including T cells, B cells, monocytes, neutrophils, and dendritic cells. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of HVEM was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. HVEM has also been demonstrated to be a unique ligand for BTLA (B and T lymphocyte attenuator). The conservation of the BTLA-HVEM interaction between mouse and human suggests that this system is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response.

TNFRSF14 is a member of the TNF-receptor superfamily. TNFRSF14 was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to TNFRSF14 has been shown to be part of the viral entry mechanism. The cytoplasmic region of TNFRSF14 was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Activation of the signal transduction pathway involving TNFRSF14 in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these TNFRSF14 variants have not been determined.

Specifications

Antigen TNFRSF14 Chimeric
Applications Flow Cytometry, Functional Assay, Inhibition Assays, Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Clone HMHV-1B18
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene TNFRSF14
Gene Accession No. Q80WM9
Gene Alias Atar; CD270; CD40-like protein; herpes virus entry mediator; herpes virus entry mediator A; Herpesvirus entry mediator A; HGNC:11912; HVEA; Hvem; LIGHTR; RP3-395M20.6; sCD2710; TNF receptor superfamily member 14; Tnfrs14; TNFRSF14; TR2; tumo; Tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor superfamily, member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); Tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2; UNQ329/PRO509
Gene Symbols TNFRSF14
Host Species Armenian Hamster
Immunogen This antibody was raised by immunising Armenian hamsters with mouse HVEM:Fc fusion protein.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 230979
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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