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Invitrogen™ TLX Polyclonal Antibody
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Catalog No. PIPA589187
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100 μL
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Catalog No. Quantity
PIPA589187 100 μL
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Catalog No. PIPA589187 Supplier Invitrogen™ Supplier No. PA589187

Description

Rabbit Polyclonal Antibody

Immunogen sequence: YFRGHKEENG AAAHFPSAAL PAPAFFTAVT QLEPHGLELA AVSTTPERQT LVSLAQPTPK YPHEVNGTPM YLYEVATESV CESAARLLFM SIKWAKSVPA FSTLSLQDQL MLLEDAWREL FVLGIAQWAI PVDANTLLAV SGMNGDNTDS QKLNKIISEI QALQEVVARF RQLRLDATEF ACLKCIVTFK AVPTHSGSEL RSFRNAAAIA ALQDEAQLTL NSYIHTRYPT QPCRFGKLLL LLPALRSISP STIEEVFFKK TIGNVPITRL LSDMYKSSDI; Positive Samples: HL-60, HepG2; Cellular Location: Nucleus.

Nuclear receptor TLX, a NR2 hepatocyte NF4-like receptor, has been shown to affect anterior brain differentiation, retinal development, and vision. It has been suggested that TLX targets genes for RAR beta2 and Pax2 during retinal development. Homozygous TLX mutant mice are viable at birth but exhibit reduced forebrain development and are more aggressive than wild-type mice. Mice with deleted TLX locus exhibit cerebral hypoplasia, blindness, and extreme aggression (fierce (frc) phenotype). TLX expression has been documented in mouse brain and eye. ESTs have been isolated from normal human brain libraries.

Specifications

Antigen TLX
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.93 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene NR2E1
Gene Accession No. Q9Y466
Gene Alias fc30e03; fc39f12; fierce; frc; HTll; Mtl1; Mtll; NR2D1; nr2e1; Nuclear receptor subfamily 2 group E member 1; nuclear receptor subfamily 2, group E, member 1; nuclear receptor TLX; Protein tailless homolog; tailes-related receptor; tailless; tailless homolog; TLL; Tlx; wu:fc30e03; wu:fc39f12; XTLL; zgc:100991
Gene Symbols NR2E1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 106-385 of human NR2E1/TLX (NP_0032601).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7101
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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