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Invitrogen™ Thymidylate Synthase Recombinant Rabbit Monoclonal Antibody (HL1236)
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Catalog No. PIMA546968
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100 μL
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Catalog No. Quantity
PIMA546968 100 μL
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Catalog No. PIMA546968 Supplier Invitrogen™ Supplier No. MA546968
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Description

Rabbit Recombinant Monoclonal Antibody

Store as concentrated solution. Centrifuge briefly prior to opening vial.

Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Specifications

Antigen Thymidylate Synthase
Applications Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone HL1236
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene TYMS
Gene Accession No. P04818, P07607, P45352
Gene Alias HST422; MGC88736; OK/SW-cl.29; Thymidylate synthase; thymidylate synthetase; TMS; TS; Tsase; Tyms; tysy
Gene Symbols TYMS
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Thymidylate synthase. The exact sequence is proprietary.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 101091231, 22171, 29261, 607417, 7298
Target Species Human, Mouse, Rat, Canine, Feline
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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