Invitrogen™ TET1 Polyclonal Antibody

Description

Immunogen sequence: VPPNPIATFN APSKWPEPQS TVSYGLAVQG AIQILPLGSG HTPQSSSNSE KNSLPPVMAI SNVENEKQVH ISFLPANTQG FPLAPERGLF HASLGIAQLS QAGPSKSDRG SSQVSVTSTV HVVNTTVVTM PVPMVSTSSS SYTT Highest antigen sequence identity to the following orthologs: Mouse - 46%, Rat - 47%.

Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.