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Invitrogen™ SynGAP Polyclonal Antibody
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Catalog No. pa1046
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100 μg
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Catalog No. Quantity
PA1046 100 μg
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Catalog No. PA1046 Supplier Invitrogen™ Supplier No. PA1046
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Description

Rabbit Polyclonal Antibody

PA1-046 detects synaptic Ras-GTPase activating protein (SynGAP) from mouse and rat tissues. The PA1-046 has been successfully used in Western blot and immunocytochemistry procedures. By Western blot, this antibody detects an ~135 kDa protein representing SynGAP from mouse brain tissue homogenate. Immunocytochemical staining of SynGAP in rat hippocampal neurons with PA1-046 yields a pattern consistent with vesicular staining. PA1-046 immunogen is residues 947-1167 of rat SynGAP.

Synaptic Ras-GTPase activating protein (SynGAP) is a PDZ-domain interacting protein expressed almost exclusively in the brain. SynGAP has been shown to be a major component of postsynaptic density and associates with post synaptic density 95 kDa (PSD-95), a synaptic scaffold protein, and synaptic N-methyl-D-aspartate (NMDA) receptors. SynGAP Ras-GTPase activity has also been shown to be inhibited by phosphorylation by CaM kinase II, another abundant protein located in the postsynaptic density. It has been proposed that SynGAP may function as a negative regulator of MAP Kinase activation in the absence of active NMDA receptors.

Specifications

Antigen SynGAP
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide
Gene SYNGAP1
Gene Accession No. F6SEU4, Q96PV0, Q9QUH6
Gene Alias DKFZp761G1421; Gm1963; KIAA1938; MRD5; Neuronal R; Neuronal RasGAP; OTTHUMP00000209046; p135 SynGAP; Ras GTPase-activating protein SynGAP; ras/Rap GTPase-activating protein SynGAP; RASA1; RASA5; synaptic Ras GTPase activating protein 1; synaptic Ras GTPase activating protein 1 homolog; synaptic Ras GTPase activating protein 1 homolog (rat); synaptic Ras GTPase activating protein, 135kDa; synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; SYNGAP; Syngap1
Gene Symbols SYNGAP1
Host Species Rabbit
Immunogen GST fusion protein of a recombinant fragment, residues 947-1167, of rat SynGAP.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 192117, 240057, 8831
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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