missing translation for 'onlineSavingsMsg'
Learn More
Learn More
MilliporeSigma™ Synaptophysin, Mouse, Unlabeled, Clone: SY38,
Mouse Monoclonal Antibody
Supplier: MilliporeSigma™ MAB5258I
Description
Synaptophysin (UniProt P20488; also known as Major synaptic vesicle protein p38) is encoded by the SYP gene (Gene ID 280937) in bovine species. Synaptophysin is a 38kDa four-transmembrane glycoprotein on synaptic vesicle (SV) with both its N- and C-termini exposed cytoplasmically. Synaptophysin forms homomultimers in the SV membrane and is heavily phosphorylated on tyrosine residues in its C-terminal pentapeptide repeats. Synapthophysin is also known to interact with SV v-SNARE protein synaptobrevin II (sybII) when sybII is not engaged with other SNARE proteins, suggesting a role of synaptophysin in sybII retrieval during SV endocytosis. Consistently, synaptophysin-knockout neurons display reduced level of sybII at their nerve terminals.Specifications
| Synaptophysin | |
| Monoclonal | |
| Please refer to lot specific datasheet. | |
| Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide. | |
| P20488 | |
| Presynaptic vesicles from bovine brain (Wiedenmann, B., and Franke, W.W. (1985). Cell. 41(3):1017-1028). | |
| 100 μL | |
| Neuroscience | |
| NP_776388 | |
| Bovine | |
| Purified |
| Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
| SY38 | |
| Unconjugated | |
| SYP | |
| Mouse | |
| Protein G Purified | |
| RUO | |
| Primary | |
| Clone SY38 detects synaptophysin and stains synaptophysin-containing vesicles by targeting the flexible segment -SGGGG- in the center of the C-termimal pentapeptide repeats (Knaus, P., and Betz, H. (1990). FEBS Lett. 261(2):358-360). | |
| Stable for 1 year at 2°-8°C from date of receipt. | |
| IgG1 κ |
For Research Use Only. Not for use in diagnostic procedures.