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Syk Mouse anti-Human, Clone: 4D10.1, eBioscience™

Mouse Monoclonal Antibody

$143.88 - $355.08

Specifications

Antigen Syk
Clone 4D10.1
Host Species Murine
Applications Flow Cytometry,Western Blot
Regulatory Status RUO
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
50245584 Life Technologies
LS14669680
25μg Each for $143.88
50245585 Life Technologies
LS14669682
100μg Each for $355.08
Specifications

Description

This 4D10.1 monoclonal antibody recognizes human Syk, a 72kDa member of the Syk/ZAP-70 family of non-receptor protein tyrosine kinases. Syk is expressed most highly in B cells, with lower expression in immature thymocytes, mast cells, and platelets. Syk can also be detected in fibroblasts, epithelial cells, hepatocytes, endothelial cells, and neuronal cells. This protein is a major component of signaling cascades downstream of the B and T cell antigen receptors and plays an essential role in lymphocyte development. Upon recruitment to immunoreceptor tyrosine-based activation motifs (ITAMs) on the antigen receptors, Syk is activated by phosphorylation on multiple tyrosines. Once activated, Syk phosphorylates proteins such as phospholipase C gamma and BLNK/SLP-65. Finally, abnormal Syk expression has been linked to tumor cell migration and invasion in several cancers.
Description & Specifications

Specifications

Syk
Murine
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
4D10.1
Flow Cytometry,Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL