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Invitrogen™ STIM1 Monoclonal Antibody (CDN3H4)
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Catalog No. 01676186
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100 μg
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Catalog No. Quantity
01676186 100 μg
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Catalog No. 01676186 Supplier Invitrogen™ Supplier No. MA119451
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Description

Mouse Monoclonal Antibody

This antibody reacts with a cytoplasmic epitope of human and rodent STIM1, a 84 kDa essential and conserved regulator of store-operated Ca2+ channel function. Western Blot: Both reducing and non-reducing conditions; Immunocytochemistry: Methanol-acetone fixation.

STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.

Specifications

Antigen STIM1
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone CDN3H4
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene STIM1
Gene Accession No. P70302, P84903, Q13586
Gene Alias D11S4896E; GOK; IMD10; RGD:1306831}; SIM; Stim1; stim1 {ECO:0000312; STIM1L; STRMK; Stromal interaction molecule 1; stromal interaction molecule 1 precursor; TAM; TAM1
Gene Symbols STIM1
Host Species Mouse
Immunogen Synthetic peptide corresponding to the C-terminal cytoplasmic part of STIM1.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20866, 361618, 6786
Target Species Human, Mouse, Rat
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1
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