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Invitrogen™ SPRYD2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA521170
Description
A suggested positive control is mouse heart tissue lysate. PA5-21170 can be used with blocking peptide PEP-1284.
SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.Specifications
| SPRYD2 | |
| Polyclonal | |
| Unconjugated | |
| CMYA5 | |
| 2310076E16Rik; 2310076E21Rik; AA420382; AI504003; C5orf10; cardiomyopathy associated 5; cardiomyopathy-associated protein 5; CMYA5; DTNBP2; Dystrobrevin-binding protein 2; genethonin-3; heart and skeletal muscle-specific and sprouty domain-containing; myospryn; SPRY domain-containing protein 2; SPRYD2; sr553; Srfsd; stretch response protein 553; stretch-response protein 553; stretch-responsive fibronectin protein type 3; Tims; TRIM76; TRIM-like protein; tripartite motif-containing 76; tripartite motif-containing protein 76 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 202333, 688915, 76469 | |
| Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C | |
| Liquid |
| Immunohistochemistry, Western Blot | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| Q70KF4, Q8N3K9 | |
| CMYA5 | |
| An 18 amino acid peptide near the carboxy terminus of human SPRYD2. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |