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Invitrogen™ SMC1 Polyclonal Antibody
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Catalog No. PIPA5115928
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PIPA5115928 100 μL
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Catalog No. PIPA5115928 Supplier Invitrogen™ Supplier No. PA5115928
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SMC1.

Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromo proteins are conserved in eukaryotes and lead to mitotic chromosome segregatior defects. This suggests a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. Mutations in the gene can lead to Cornelia de Lange syndrome 2.

Specifications

Antigen SMC1
Applications Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene SMC1A
Gene Accession No. Q14683, Q8NDV3, Q920F6, Q9CU62
Gene Alias 14S cohesin SMC1 subunit; 5830426I24Rik; CDLS2; chromosome segregation protein SmcB; DKFZp686L19178; DXhXs423e; DXS423E; KIAA0178; MGC138332; mitosis-specific chromosome segregation protein like protein beta; mKIAA0178; RP6-29D12.1; Sb1.8; segregation of mitotic chromosomes 1; segregation of mitotic chromosomes b; segregation of mitotic chromosomes-like 1; SM1A; SMC; SMC (segregation of mitotic chromosomes 1)-like 1; SMC protein; SMC protein 1A; SMC protein 1B; SMC1; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 protein; SMC1 protein cohesin subunit; SMC1 structural maintenance of chromosomes 1-like 1; SMC1 structural maintenance of chromosomes 1-like 2; Smc1a; SMC-1A; smc1a.L; smc1aa; Smc1alpha; SMC-1-alpha; SMC1alpha protein; Smc1b; SMC-1B; SMC1BETA; SMC-1-beta; SMC1L1; Smc1l2; Smcb; SMC-like 1; SMC-protein; structural maintenace of chromosomes 1B; structural maintenance of chromosomes 1; structural maintenance of chromosomes 1 like 1; structural maintenance of chromosomes 1A; structural maintenance of chromosomes 1A a; structural maintenance of chromosomes 1A L homeolog; structural maintenance of chromosomes 1B; structural maintenance of chromosomes protein 1A; Structural maintenance of chromosomes protein 1B; Unknown (protein for IMAGE:8058685); XELAEV_18000030mg; xsmc1
Gene Symbols SMC1A, SMC1B
Host Species Rabbit
Immunogen A synthesized peptide derived from human SMC1A(Accession Q14683), corresponding to amino acid residues Q931-I981.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 140557, 24061, 27127, 8243
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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