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Invitrogen™ SMAD4 Recombinant Rabbit Monoclonal Antibody (23GB975)
Rabbit Recombinant Monoclonal Antibody
$656.94 - $1,779.35
Specifications
| Antigen | SMAD4 |
|---|---|
| Clone | 23GB975 |
| Content And Storage | -20°C |
| Applications | Flow Cytometry, Western Blot, Immunocytochemistry |
| Classification | Recombinant Monoclonal |
Description
SMAD4 Recombinant Monoclonal Antibody for Western Blot, ICC/IF, Flow
Smad4 is encoded by the Smad4 gene that is located on chromosome 18 in humans. Smad4 is also known as Smad family member 4, Sma- and Mad-relatedprotein 4 or Mothers against decapentaplegic (MAD) homolog 4. Smad4 contains N-terminal MH1 (MAD homology 1) and C-terminal MH2 (MAD homology 2) globular domains that are involved in DNA binding and protein interactions respectively. Binding of the TGF-beta superfamily of ligands that includes Transforming Growth Factor -beta (TGF-beta) and bone morphogenetic protein (BMP) to its cognate receptor allows phosphorylation of Smad 1, 2, 3, 5 and 8 (R-Smad, Receptor Smad). This signals for heterotrimerization with Smad4 (co-Smad, co-mediator Smad) and translocation of the complex to the nucleus. Inhibitory or antagonistic Smad (I-Smad) that includes Smad 6 and 7, interact with activated R-Smads and attenuate the signaling pathway. Smad4 acts as a tumor suppressor protein by transcriptionally regulating its target genes such as Cyclin D1 (downregulation) and collagen (upregulation) that inhibit cell proliferation. Dephosphorylation regulates nuclear export and nucleocytoplasmic dynamics of Smads.Specifications
| SMAD4 | |
| -20°C | |
| Recombinant Monoclonal | |
| Liquid | |
| IgG | |
| Human, Mouse, Rat | |
| SMAD4 | |
| AW743858; D18Wsu70e; Deleted in Pancreatic Carcinoma 4 (DPC4); deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; Deletion target in pancreatic carcinoma 4 homolog; DPC4; hSMAD4; JIP; MAD (mothers against decapentaplegic Drosophila) homolog 4; MAD homolog 4; MAD homolog 4 (MADH4); Madh4; mothers against decapentaplegic homolog 4; Mothers against decapentaplegic homolog 4 (MADH4); mothers against decapentaplegic, Drosophila, homolog of, 4; mothers against DPP homolog 4; MYHRS; SMAD; SMAD 4; SMAD family member 4; SMAD, mothers against DPP homolog 4; SMAD4 | |
| SMAD4 | |
| Primary | |
| Affinity chromatography |
| 23GB975 | |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| Unconjugated | |
| Rabbit | |
| RUO | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| O70437, P97471, Q13485 | |
| 17128, 4089, 50554 | |
| A synthetic peptide of human Smad4 (500-552AA). | |
| Antibody |