Invitrogen™ SLC4A10 Polyclonal Antibody

Description

Immunogen sequence: FELSEAYPIN MHNDLELLTQ YSCNCVEPHN PSNGTLKEWR ESNISASDII WENLT Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 91%.

Members of the SLC4 bicarbonate transporter family are involved in solute transport and pH homeostasis. NCBE (SLC4A10) is a member of the SLC4 family of bicarbonate transporters, several of which play important roles in intracellular-pH regulation and transepithelial HCO(3)(-) transport. The SLC4A10 gene, which is highly expressed in the mammalian brain, contains two known alternative splicing units, inserts A and B. SLC4A10 encodes a sodium bicarbonate transporter with a brain-restricted expression pattern. Slc4a10 knockout (KO) mice have collapsed brain ventricles and display an increased seizure threshold, while heterozygous deletions in man have been associated with idiopathic epilepsy and other neurological symptoms. Slc4a10 is a promising pharmacological target for the therapy of epilepsy or elevated intracranial pressure.