Invitrogen™ SIK3 Polyclonal Antibody

Description

Immunogen sequence: QQEYQELFRH MNQGDAGSLA PSLGGQSMTE RQALSYQNAD SYHHHTSPQH LLQIRAQECV SQASSPTPPH GYAHQPALMH SESMEEDCSC EGAKDGFQD Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 80%.

SIK3 (QSK) is a serine/threonine-protein kinase, belongs to QIK subfamily. The phosphorylation of SIK3 by LKB1 through the 14-3-3 binding enhances its catalytic activity and leads its localization to punctate structures within the cytoplasm. Overexpression of SIK3 promotes G1/S cell cycle progression with ovarian cancer. There are two sites (H331L and A1103V) were mutated at significant frequency in breast cancer. SIK3 is a novel tumor-associated antigen (TAA). SIK3 is a positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3.