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Invitrogen™ SIK2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA141208
Description
Suggested positive control: human brain tissue, human brain protein.
SNF1LK2 (QIK) is a serine/threonine kinase and is a salt-inducible kinase that belongs to the AMP-activated protein kinase family. SNF1LK2 negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1'alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.Specifications
| SIK2 | |
| Polyclonal | |
| Unconjugated | |
| SIK2 | |
| G630080D20Rik; KIAA0781; LOH11CR1I; QIK; Qin-induced kinase; RGD1559698; salt induceable kinase 2; salt inducible kinase 2; salt-inducible kinase 2; salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; Sik2; SIK-2; SNF1-like kinase 2; SNF1LK2 | |
| Rabbit | |
| Protein G | |
| RUO | |
| 23235, 235344, 315649, 489410, 539570 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 0.05% sodium azide | |
| Q8CFH6, Q9H0K1 | |
| SIK2 | |
| A portion of amino acids 100-150 of human SIK2. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat, Canine, Monkey, Bovine | |
| Antibody | |
| IgG |