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Invitrogen™ SCO2 Polyclonal Antibody
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Catalog No. PIPA563275
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100 μL
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PIPA563275 100 μL
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Catalog No. PIPA563275 Supplier Invitrogen™ Supplier No. PA563275
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PTAWHRLSQL KPRVLPGTLG GQALHLRSWL LSRQGPAETG GQGQPQGPGL RTRLLITGLF GAGLGGAWLA LRAEKERLQQ QKRTEALRQA AVGQGDFHLL DHRG Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 26%.

Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.

Specifications

Antigen SCO2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Sco2
Gene Accession No. O43819
Gene Alias CEMCOX1; MYP6; protein SCO2 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 2; SCO cytochrome oxidase deficient homolog 2 (yeast); SCO1L; SCO2; SCO2 cytochrome c oxidase assembly protein
Gene Symbols Sco2
Host Species Rabbit
Immunogen Recombinant protein fragment of Human SCO2 (Product #RP-91549)
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9997
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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