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Thermo Scientific Chemicals SB 225002

Catalog No. AAJ65387MA
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AAJ65387MA 10 mg
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Catalog No. AAJ65387MA Supplier Thermo Scientific Chemicals Supplier No. J65387MA
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Description

A potent, selective and competitive antagonist of the G-protein coupled receptor CXCR2

SB 225002 is a selective non-peptide CXCR2 inhibitor which suppresses IL-8 induced neutrophil chemotaxis and margination. In addition, SB 225002 reduces MPO activity, IL-1β, MIP-2, and keratinocyte-derived chemokine (KC) levels. Further studies suggest that SB 225002 decreases the expression of vascular endothelial growth factor, inducible NOS (NO synthase), and Cox-2 (cyclooxygenase-2 proteins) in colon tissue.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Chemical Identifiers

CAS 182498-32-4
Molecular Formula C13H10BrN3O4
Synonym 1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea

Specifications

Quantity 10 mg
Description Yellow
Content And Storage -30°C to -10°C
For Use With (Application) A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2
Formula Weight 352.10g/mol
Sensitivity Moisture Sensitive
Solubility Soluble to 100mM in DMSO and to 50mM in ethanol
Product Type Signal Transduction Reagent
Form Solid
InChI Key MQBZVUNNWUIPMK-UHFFFAOYSA-N
SMILES OC1=C(NC(=O)NC2=CC=CC=C2Br)C=CC(=C1)[N+]([O-])=O
IUPAC Name 3-(2-bromophenyl)-1-(2-hydroxy-4-nitrophenyl)urea
Molecular Weight (g/mol) 352.14
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Safety and Handling

Recommended Storage Store at -20°C; Store under Nitrogen

RUO – Research Use Only