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Thermo Scientific Chemicals SB 225002
A potent, selective and competitive antagonist of the G-protein coupled receptor CXCR2
Supplier: Thermo Scientific Chemicals J65387MA
| Quantity | 10 mg |
|---|
Description
SB 225002 is a selective non-peptide CXCR2 inhibitor which suppresses IL-8 induced neutrophil chemotaxis and margination. In addition, SB 225002 reduces MPO activity, IL-1β, MIP-2, and keratinocyte-derived chemokine (KC) levels. Further studies suggest that SB 225002 decreases the expression of vascular endothelial growth factor, inducible NOS (NO synthase), and Cox-2 (cyclooxygenase-2 proteins) in colon tissue.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Chemical Identifiers
| 182498-32-4 | |
| C13H10BrN3O4, C13H10BrN3O4 | |
| 1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea |
Specifications
| 10 mg | |
| -30°C to -10°C | |
| 182498-32-4 | |
| 352.10g/mol | |
| Moisture Sensitive | |
| Signal Transduction Reagent | |
| MQBZVUNNWUIPMK-UHFFFAOYSA-N | |
| 3-(2-bromophenyl)-1-(2-hydroxy-4-nitrophenyl)urea |
| Yellow | |
| A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2 | |
| C13H10BrN3O4, C13H10BrN3O4 | |
| 1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea | |
| Soluble to 100mM in DMSO and to 50mM in ethanol | |
| Solid | |
| OC1=C(NC(=O)NC2=CC=CC=C2Br)C=CC(=C1)[N+]([O-])=O | |
| 352.14 |
Safety and Handling
Recommended Storage : Store at -20°C; Store under Nitrogen