Invitrogen™ RNF186 Polyclonal Antibody

The RNF186 gene encodes the RING finger protein 186, a member of the RING-type E3 ubiquitin ligase family. RNF186 is involved in the ubiquitin-proteasome pathway, playing a crucial role in tagging target proteins for degradation, thus influencing protein turnover and cellular homeostasis. This process is essential for regulating various cellular functions, including signal transduction, apoptosis, and response to stress. RNF186 has been implicated in the unfolded protein response (UPR) within the endoplasmic reticulum, where it helps in managing protein folding and maintaining cellular homeostasis, particularly under conditions of endoplasmic reticulum stress. Alterations in RNF186 expression or function have been associated with disorders such as inflammatory bowel disease and ulcerative colitis, suggesting its role in gastrointestinal health and disease. Research into RNF186 focuses on its regulatory mechanisms within the ubiquitin-proteasome system and its potential as a therapeutic target for conditions associated with protein misfolding and cellular stress responses.