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Gibco™ Rat SCF, Animal-Free Recombinant Protein, PeproTech® 
Recombinant Protein
$339.00 - $5010.00
Specifications
| Accession Number | P21581 |
|---|---|
| For Use With (Application) | Functional Assay |
| Formulation | protein with no preservative |
| Gene ID (Entrez) | 60427 |
| Molecular Weight (g/mol) | 18.4 kDa |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AF40022100
|
Gibco™
AF40022100UG |
100 μg |
Each for $1,038.00
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AF4002210UG
|
Gibco™
AF4002210UG |
10 μg |
Each for $339.00
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AF400221MG
|
Gibco™
AF400221MG |
1 mg |
Each for $5,010.00
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AF40022500
|
Gibco™
AF40022500UG |
500 μg |
Each for $3,005.00
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Description
Recombinant Rat SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.Specifications
| P21581 | |
| protein with no preservative | |
| 18.4 kDa | |
| E. coli | |
| <0.1 EU/ μg | |
| SCF | |
| Determined by the dose-dependent stimulation of the proliferation of the human TF-1 cells. The expected ED50 for this effect is 20 - 40 ng/ml | |
| Recombinant | |
| -20°C | |
| Lyophilized |
| Functional Assay | |
| 60427 | |
| Rat SCF, Animal-Free | |
| RUO | |
| 710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; Mast cell growth factor; MGF; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; SLF; Soluble KIT ligand; Steel factor; steel factor/kit ligand; stem cell factor; stem cell factor KL-1; stem cell factor, CSF | |
| KITLG | |
| Unconjugated | |
| MQEICRNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWLRDMV THLSVSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVAC MEENAPKNVK ESLKKPETRN FTPEEFFSIF NRSIDAFKDF MVASDTSDCV LSSTLGPEKD SRVSVTKPFM LPPVA | |
| E. coli | |
| ≥ 98% by SDS-PAGE gel and HPLC analyses. |