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Gibco™ Rat CNTF, Animal-Free Recombinant Protein, PeproTech®

Catalog No. AF450505UG
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250 μg
5 μg
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Catalog No. Quantity
AF450505UG 5 μg
AF45050250U 250 μg
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Catalog No. AF450505UG Supplier Gibco™ Supplier No. AF450505UG

Description

Recombinant Protein

Recombinant Rat CNTF is synthesized as a 199 amino acid polypeptide (22.7 kDa) lacking a hydrophobic N-terminal signal for secretion. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of ZFP91 and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.

Specifications

Accession Number P20294
For Use With (Application) Control, Bioactivity
Format Lyophilized
Formulation Protein with no preservative
Gene ID (Entrez) 25707
Molecular Weight (g/mol) 22.7 kDa
Name Rat CNTF, Animal-Free
Purification Method Purified
Quantity 5 μg
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <0.1 EU/μg
Gene Alias AI429687; Ciliary neurotrophic factor; ciliary neurotropic factor; Cntf; HCNTF; H-CNTF
Common Name CNTF
Gene Symbol CNTF
Biological Activity Determined by its ability to stimulate proliferation of human TF-1 cells using a concentration range of 25.0-35.0 ng/ml
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence AFAEQTPLTL HRRDLCSRSI WLARKIRSDL TALMESYVKH QGLNKNINLD SVDGVPVAST DRWSEMTEAE RLQENLQAYR TFQGMLTKLL EDQRVHFTPT EGDFHQAIHT LMLQVSAFAY QLEELMVLLE QKIPENEADG MPATVGDGGL FEKKLWGLKV LQELSQWTVR SIHDLRVISS HQMGISALES HYGAKDKQM
Content And Storage -20°C
Activity Determined by its ability to stimulate proliferation of human TF-1 cells using a concentration range of 25.0-35.0 ng/ml.
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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