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Invitrogen™ Ras (G12D Mutant) Recombinant Rabbit Monoclonal Antibody (HL10)
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Catalog No. PIMA536256
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PIMA536256 100 μL
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Catalog No. PIMA536256 Supplier Invitrogen™ Supplier No. MA536256

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Description

Rabbit Recombinant Monoclonal Antibody

Ras (G12D Mutant) Recombinant Monoclonal Antibody for IHC (P), Western Blot

Ras is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. The process of shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in Ras gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

Specifications

Antigen Ras (G12D Mutant)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone HL10
Concentration 1.5 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene NRAS
Gene Accession No. P01111, P08556
Gene Alias ALPS4; AV095280; CMNS; GTPase NRas; HRAS1; NCMS; neuroblastoma ras oncogene; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; NRAS; N-ras; N-ras protein part 4; NRAS1; NS6; transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog
Gene Symbols NRAS
Host Species Rabbit
Immunogen Carrier-protein conjugated synthetic peptide surrounding mutant G12D of human K-Ras. The exact sequence is proprietary.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18176, 4893
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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