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Invitrogen™ PUMA alpha Monoclonal Antibody (2A8F6)
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Catalog No. PIMA515752
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100 μg
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Catalog No. Quantity
PIMA515752 100 μg
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Catalog No. PIMA515752 Supplier Invitrogen™ Supplier No. MA515752
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Description

Mouse Monoclonal Antibody

A suggested positive control is K562 cell lysate.

PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.

Specifications

Antigen PUMA alpha
Applications Western Blot
Classification Monoclonal
Clone 2A8F6
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene BBC3
Gene Accession No. Q80ZG6, Q9BXH1
Gene Alias BBC3; BCL2 binding component 3; Bcl-2 binding component 3; bcl-2-binding component 3; Bcl-2-binding component 3, isoforms 1/2; Bcl-2-binding component 3, isoforms 3/4; BH3-only; FLJ42994; JFY1; JFY-1; p53 up-regulated modulator of apoptosis; PUMA; PUMA/JFY1
Gene Symbols BBC3
Host Species Mouse
Immunogen Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27113, 317673
Target Species Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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