Invitrogen™ PTTG2 Polyclonal Antibody

Description

Recommended positive controls: NT2D1, IMR32, U87-MG. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The PTTG2 (Pituitary Tumor-Transforming Gene 2) gene is part of a family of securin proteins involved in regulating sister chromatid separation during cell division. Located on chromosome 8q13, PTTG2 acts as a securin, inhibiting separase to prevent premature separation of sister chromatids until proper chromosome alignment is achieved during mitosis. PTTG2 is expressed in various tissues and has been implicated in tumorigenesis due to its role in cell cycle regulation and its potential to induce genetic instability when dysregulated. Overexpression of PTTG2 has been observed in several cancers, including pituitary adenomas, and is associated with increased cell proliferation, invasion, and metastasis. Due to its involvement in mitotic regulation and tumor development, PTTG2 is considered a potential biomarker for cancer diagnosis and prognosis, as well as a target for therapeutic intervention. Understanding the molecular mechanisms regulated by PTTG2 could aid in the development of novel cancer treatments.