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Invitrogen™ Prolactin Receptor Monoclonal Antibody (1A2B1)
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Catalog No. 359200
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100 μg
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Catalog No. Quantity
359200 100 μg
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Catalog No. 359200 Supplier Invitrogen™ Supplier No. 359200
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Description

Mouse Monoclonal Antibody

This antibody is predicted to react with mouse and rat and reacts with the long form of the human prolactin receptor (hPRLr) protein at ~85-90 kDa, and may also identify the human prolactin receptor intermediate and delta S1 isoforms by western blotting. On immunoprecipitation, this antibody strongly recognizes only the long form of hPRLr. During development reactivity was confirmed with human T-47D breast carcinoma cells.

Prolactin (PRL) is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor (PRLR), a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. PRLR consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.

Specifications

Antigen Prolactin Receptor
Applications Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 1A2B1
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene PRLR
Gene Accession No. P16471
Gene Alias AI987712; cytokine receptor; HPRL; hPRL receptor; hPRLrI; Lactogen receptor; MFAB; pPRLR-SF; Pr-1; Pr-3; Prl R; PRLR; PRL-R; Prlr-rs1; Prolactin receptor; prolactin receptor 2 precursor; prolactin receptor related sequence 1; prolactin receptor short isoform; RATPRLR; secreted prolactin binding protein
Gene Symbols PRLR
Host Species Mouse
Immunogen Recombinant human prolactin receptor protein containing the extracellular domain (ECD).
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5618
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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