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Invitrogen™ PKLR Polyclonal Antibody
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Catalog No. pipa527305
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100 μL
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Catalog No. Quantity
PIPA527305 100 μL
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Catalog No. PIPA527305 Supplier Invitrogen™ Supplier No. PA527305
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: Jurkat, Raji, K562, rat liver, PKLR-transfected 293T. Predicted reactivity: Mouse (93%), Rat (92%), Xenopus laevis (80%), Dog (93%), Bovine (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

Antigen PKLR
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.01 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene PKLR
Gene Accession No. P12928, P30613
Gene Alias isozymes R/L; L-PK; PK1; Pk-1; PKL; Pklg; Pklr; PKR; PKRL; Pyruvate kinase 1; pyruvate kinase isozyme R/L; pyruvate kinase isozymes L/R; pyruvate kinase isozymes R/L; pyruvate kinase liver and red blood cell; pyruvate kinase PKLR; pyruvate kinase type L; pyruvate kinase, liver and blood cell; pyruvate kinase, liver and RBC; pyruvate kinase, liver and red blood cell; red cell/liver pyruvate kinase; RPK; R-PK; R-type/L-type pyruvate kinase
Gene Symbols PKLR
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Pyruvate Kinase (liver/RBC). The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 24651, 5313
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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