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Invitrogen™ PKA alpha/beta/gamma Polyclonal Antibody
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Catalog No. PIPA567660
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100 μL
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Catalog No. Quantity
PIPA567660 100 μL
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Catalog No. PIPA567660 Supplier Invitrogen™ Supplier No. PA567660

Description

Rabbit Polyclonal Antibody

PKA alpha/beta/gamma Polyclonal Antibody for Western Blot, ICC/IF

Protein kinase A (PKA, cAMP-dependent protein kinase) is a key element of a ubiquitous signaling pathway important in the cell cycle, cellular communication, memory formation and behavior. PKA is composed of two catalytic (PKAc; Protein Kinase A catalytic subunit) and two regulatory subunits (PKAr). Upon binding cAMP, the complex dissociates to PKAr dimer and two activated PKAc ser/thr protein kinase catalytic monomers. The released PKAc can translocate into the nucleus and exert a regulatory role in the activation of multiple nuclear hormone receptors. However, PKAc-mediated activation of tonicity-dependent gene expression is cAMP independent. Humans express three types of PKAc subunit - PKAc alpha is present in most human tissues, PKAc beta and gamma are tissue-specific, the later is found in testes.

Specifications

Antigen PKA alpha/beta/gamma
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PRKACA
Gene Accession No. P17252, P22612, P22694
Gene Alias BDPLT19; cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; cAMP-dependent protein kinase catalytic subunit beta; cAMP-dependent protein kinase catalytic subunit gamma; KAPG; PKA C-alpha; PKA C-beta; PKA C-gamma; PKACA; PKACB; PKACg; PPNAD4; PRKACA; PRKACB; PRKACG; protein kinase A catalytic subunit; protein kinase A catalytic subunit beta; protein kinase cAMP-activated catalytic subunit alpha; protein kinase cAMP-activated catalytic subunit beta; protein kinase cAMP-activated catalytic subunit gamma; protein kinase, cAMP-dependent, alpha catalytic subunit; protein kinase, cAMP-dependent, beta catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha; protein kinase, cAMP-dependent, catalytic, beta; protein kinase, cAMP-dependent, catalytic, gamma; protein kinase, cAMP-dependent, gamma catalytic subunit; serine(threonine) protein kinase
Gene Symbols PRKACA, PRKACB, PRKACG
Host Species Rabbit
Immunogen Synthesized peptide derived from human PKA alpha/beta/gamma.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5566, 5567, 5568
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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