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Invitrogen™ PIASy Polyclonal Antibody
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Catalog No. PIPA520954
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100 μg
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Catalog No. Quantity
PIPA520954 100 μg
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Catalog No. PIPA520954 Supplier Invitrogen™ Supplier No. PA520954
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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat brain tissue lysate. PA5-20954 can be used with blocking peptide PEP-1068.

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. [UniProt].

Specifications

Antigen PIASy
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene PIAS4
Gene Accession No. Q8N2W9, Q9JM05
Gene Alias e3 sumo- ligase pias4; E3 SUMO-protein ligase PIAS4; FLJ12419; MGC35296; Pias4; Piasg; Pias-gamma; PIASy; protein inhibitor of activated STAT 4; protein inhibitor of activated STAT PIASy; protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; protein inhibitor of activated STAT protein PIASy; protein inhibitor of activated STAT, 4; RING-type E3 ubiquitin transferase PIAS4; zinc finger, MIZ-type containing 6; ZMIZ6
Gene Symbols PIAS4
Host Species Rabbit
Immunogen A 19 amino acid peptide near the amino terminus of human PIAS4.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 362827, 51588, 59004
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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