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Invitrogen™ Phospho-Syk (Tyr317) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ 44233G
Description
Phospho-Syk (Tyr317) Polyclonal Antibody for Western Blot
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.Chemical Identifiers
| Phospho-Syk (Tyr317) | |
| Western Blot | |
| Unconjugated | |
| Rabbit | |
| RUO | |
| Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3 | |
| P43405, P48025 | |
| 20963, 6850 | |
| The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of mouse Syk that contains tyrosine 317 (tyrosine 323 in the human sequence). | |
| Antibody |
| -20°C | |
| Polyclonal | |
| Liquid | |
| IgG | |
| Human, Mouse | |
| Syk | |
| DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; SYK; syk signaling; Sykb; tyrosine-kinase syk; tyrosine-protein kinase SYK | |
| Syk | |
| Primary | |
| Antigen affinity chromatography |
Specifications
| Phospho-Syk (Tyr317) | |
| Polyclonal | |
| Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3 | |
| P43405, P48025 | |
| Syk | |
| The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of mouse Syk that contains tyrosine 317 (tyrosine 323 in the human sequence). | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
| Western Blot | |
| Unconjugated | |
| Syk | |
| DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; SYK; syk signaling; Sykb; tyrosine-kinase syk; tyrosine-protein kinase SYK | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 20963, 6850 | |
| -20°C | |
| Liquid |