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Invitrogen™ Phospho-PRAS40 (Thr246) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA517175
Description
It is not recommended to aliquot this antibody.
The Akt signaling pathway contributes to the regulation of apoptosis after a variety of cell death signals. AKT1S1, also known as PRAS40, is a proline-rich substrate of the kinase AKT1 and is thought to play a role in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia. AKT1S1 is also a substrate and potential regulator of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Treatment with the insulin-like growth factor-1 (IGF1) can induce the phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.Chemical Identifiers
| Phospho-PRAS40 (Thr246) | |
| Western Blot, Immunocytochemistry | |
| Unconjugated | |
| Rabbit | |
| RUO | |
| 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5 | |
| Q96B36, Q9D1F4 | |
| 292887, 67605, 84335 | |
| Synthetic phosphopeptide corresponding to the sequence surrounding pThr246 of human PRAS40. | |
| Antibody |
| -20°C | |
| Polyclonal | |
| Liquid | |
| IgG | |
| Human, Mouse, Rat, Monkey | |
| AKT1S1 | |
| 1110012J22Rik; 40 kDa proline-rich AKT substrate; AI227026; AKT1 substrate 1; AKT1 substrate 1 (proline rich); AKT1 substrate 1 (proline-rich); akt1s1; Lobe; Lobel; OTTHUMP00000196756; OTTHUMP00000196760; PKB/Akt substrate 40; Pras; PRAS40; Proline-rich AKT substrate; proline-rich AKT1 substrate 1 | |
| AKT1S1 | |
| Primary | |
| Antigen affinity chromatography |
Specifications
| Phospho-PRAS40 (Thr246) | |
| Polyclonal | |
| 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5 | |
| Q96B36, Q9D1F4 | |
| AKT1S1 | |
| Synthetic phosphopeptide corresponding to the sequence surrounding pThr246 of human PRAS40. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat, Monkey | |
| Antibody | |
| IgG |
| Western Blot, Immunocytochemistry | |
| Unconjugated | |
| AKT1S1 | |
| 1110012J22Rik; 40 kDa proline-rich AKT substrate; AI227026; AKT1 substrate 1; AKT1 substrate 1 (proline rich); AKT1 substrate 1 (proline-rich); akt1s1; Lobe; Lobel; OTTHUMP00000196756; OTTHUMP00000196760; PKB/Akt substrate 40; Pras; PRAS40; Proline-rich AKT substrate; proline-rich AKT1 substrate 1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 292887, 67605, 84335 | |
| -20°C | |
| Liquid |