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Invitrogen™ Phospho-p27 Kip1 (Thr157) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA512650
Description
Phospho-p27 Kip1 (Thr157) Polyclonal Antibody for IHC (P), DB
p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.Chemical Identifiers
| Phospho-p27 Kip1 (Thr157) | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Polyclonal | |
| Liquid | |
| IgG | |
| Human | |
| Cdkn1b | |
| AA408329; AI843786; Cdki1b; CDKN1B; CDKN4; CDN1B; cyclin dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor 1B (p27 Kip1); Cyclin-dependent kinase inhibitor 1B (p27, Kip1); cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27 Kip1; cyclin-dependent kinase inhibitor p27/Kip1; KIP1; MEN1B; MEN4; p27; P27 CDKN1B; p27(KIP1); p27Kip1 | |
| Cdkn1b | |
| Primary | |
| Antigen affinity chromatography, Protein A |
| 0.4 mg/mL | |
| Dot Blot, Immunohistochemistry (Paraffin) | |
| Unconjugated | |
| Rabbit | |
| RUO | |
| PBS with 0.09% sodium azide; pH 7.4 | |
| P46527 | |
| 1027 | |
| KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T157 of human p27Kip1. | |
| Antibody |
Specifications
| Phospho-p27 Kip1 (Thr157) | |
| Polyclonal | |
| Unconjugated | |
| Cdkn1b | |
| AA408329; AI843786; Cdki1b; CDKN1B; CDKN4; CDN1B; cyclin dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor 1B (p27 Kip1); Cyclin-dependent kinase inhibitor 1B (p27, Kip1); cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27 Kip1; cyclin-dependent kinase inhibitor p27/Kip1; KIP1; MEN1B; MEN4; p27; P27 CDKN1B; p27(KIP1); p27Kip1 | |
| Rabbit | |
| Antigen affinity chromatography, Protein A | |
| RUO | |
| 1027 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Dot Blot, Immunohistochemistry (Paraffin) | |
| 0.4 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.4 | |
| P46527 | |
| Cdkn1b | |
| KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T157 of human p27Kip1. | |
| 400 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |