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Invitrogen™ Phospho-MAP2K1/MAP2K2 (Ser218, Ser222, Ser226) Polyclonal Antibody
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Catalog No. PIPA5105777
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PIPA5105777 100 μL
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Catalog No. PIPA5105777 Supplier Invitrogen™ Supplier No. PA5105777
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of MEK1/2 only when phosphorylated at S218+S222(MEK1)/S222+S226(MEK2).

MEK 1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993; Chong et al., 2003). In brain, this pathway also plays a key role in synaptic (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991; Seger et al., 1991; Crews et al., 1992).

Specifications

Antigen Phospho-MAP2K1/MAP2K2 (Ser218, Ser222, Ser226)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene MAP2K2
Gene Accession No. P31938, P36506, P36507, Q01986, Q02750, Q63932
Gene Alias AA589381; CFC3; CFC4; dual specificity mitogen activated protein kinase kinase 1; dual specificity mitogen-activated protein kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 2; EC 2.7.12.2; ERK activator kinase 1; ERK activator kinase 2; hypothetical protein; hypothetical protein LOC406728; kinase MEK1; MAP kinase kinase 1; MAP kinase kinase 2; MAP kinase/Erk kinase; MAP kinase/Erk kinase 1; Map2k1; Map2k2; MAPK/ERK kinase 1; MAPK/ERK kinase 2; MAPKK 1; MAPKK 2; MAPKK1; MAPKK2; MEK 1; MEK 2; Mek1; MEK-1; Mek2; MEK-2; MEKK1; mitogen activated protein kinase kinase 1; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 1; mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; mitogen-activated protein kinase kinase type 2; MK2; MKK1; MKK2; MP2K1; PRKMK1; PRKMK2; protein kinase, mitogen activated, kinase 1, p45; protein kinase, mitogen activated, kinase 2, p45; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); si:ch211-242m18.2; wu:fj56a12; wu:fj61b01; zgc:56557; zgc:56557 protein
Gene Symbols MAP2K1, MAP2K2
Host Species Rabbit
Immunogen A synthesized peptide derived from human MAP2K1(Accession Q02750), corresponding to amino acid residues around phosphorylated Ser226.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 170851, 26395, 26396, 5604, 5605, 58960
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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