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Invitrogen™ Phospho-MAP2K1/MAP2K2 (Ser218, Ser222, Ser226) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5105777
Description
Antibody detects endogenous levels of MEK1/2 only when phosphorylated at S218+S222(MEK1)/S222+S226(MEK2).
MEK 1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993; Chong et al., 2003). In brain, this pathway also plays a key role in synaptic (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991; Seger et al., 1991; Crews et al., 1992).Specifications
| Phospho-MAP2K1/MAP2K2 (Ser218, Ser222, Ser226) | |
| Polyclonal | |
| Unconjugated | |
| MAP2K2 | |
| AA589381; CFC3; CFC4; dual specificity mitogen activated protein kinase kinase 1; dual specificity mitogen-activated protein kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 2; EC 2.7.12.2; ERK activator kinase 1; ERK activator kinase 2; hypothetical protein; hypothetical protein LOC406728; kinase MEK1; MAP kinase kinase 1; MAP kinase kinase 2; MAP kinase/Erk kinase; MAP kinase/Erk kinase 1; Map2k1; Map2k2; MAPK/ERK kinase 1; MAPK/ERK kinase 2; MAPKK 1; MAPKK 2; MAPKK1; MAPKK2; MEK 1; MEK 2; Mek1; MEK-1; Mek2; MEK-2; MEKK1; mitogen activated protein kinase kinase 1; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 1; mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; mitogen-activated protein kinase kinase type 2; MK2; MKK1; MKK2; MP2K1; PRKMK1; PRKMK2; protein kinase, mitogen activated, kinase 1, p45; protein kinase, mitogen activated, kinase 2, p45; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); si:ch211-242m18.2; wu:fj56a12; wu:fj61b01; zgc:56557; zgc:56557 protein | |
| Rabbit | |
| Sequential chromatography | |
| RUO | |
| 170851, 26395, 26396, 5604, 5605, 58960 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P31938, P36506, P36507, Q01986, Q02750, Q63932 | |
| MAP2K1, MAP2K2 | |
| A synthesized peptide derived from human MAP2K1(Accession Q02750), corresponding to amino acid residues around phosphorylated Ser226. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |