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Invitrogen™ Phospho-LATS1/LATS2 (Ser909, Ser872) Polyclonal Antibody
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Catalog No. pipa5105895
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PIPA5105895 100 μL
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Catalog No. PIPA5105895 Supplier Invitrogen™ Supplier No. PA5105895
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of LATS1/2 only when phosphorylated at Ser909/872.

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Specifications

Antigen Phospho-LATS1/LATS2 (Ser909, Ser872)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Lats1
Gene Accession No. O95835, Q7TSJ6, Q8BYR2, Q9NRM7
Gene Alias 4932411G09Rik; AV277261; AW208599; AW228608; h-warts; kinase phosphorylated during mitosis protein; KPM; large tumor suppressor; large tumor suppressor 2; large tumor suppressor homolog 1; Large tumor suppressor homolog 2; large tumor suppressor kinase 1; large tumor suppressor kinase 2; large tumor suppressor, homolog 2; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 1; LATS, large tumor suppressor, homolog 2; lats1; Lats2; RGD1564085; serine/threonine kinase KPM; serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS1; serine/threonine-protein kinase LATS2; WARTS; WARTS protein kinase; warts-like kinase; wts
Gene Symbols Lats1, Lats2
Host Species Rabbit
Immunogen A synthesized peptide derived from human LATS1(Accession O95835), corresponding to amino acid residues around phosphorylated Ser872.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16798, 26524, 305922, 308265, 50523, 9113
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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