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  6. Invitrogen™ Phospho-EGFR (Tyr1173) Recombinant Rabbit Monoclonal Antibody (23GB3900)

Invitrogen™ Phospho-EGFR (Tyr1173) Recombinant Rabbit Monoclonal Antibody (23GB3900)

Catalog No. MA553661
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100 μL
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MA553661 20 μL
MA553660 100 μL
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Catalog No. MA553661 Supplier Invitrogen™ Supplier No. MA553661
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Description

Rabbit Recombinant Monoclonal Antibody

Phospho-EGFR (Tyr1173) Recombinant Monoclonal Antibody for Flow, ICC/IF, Western Blot

EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. EGFR is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.

Specifications

Antigen Phospho-EGFR (Tyr1173)
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 23GB3900
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene EGFR
Gene Accession No. P00533
Gene Alias 2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2
Gene Symbols EGFR
Host Species Rabbit
Immunogen A synthetic peptide of human EGFR Full-length sequence 1210aa around the phosphorylation site of Tyrosine 1197 (1166-1180AA).
Purification Method Affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1956, 24329
Target Species Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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