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Invitrogen™ Phospho-c-Raf (Ser642) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA14640
Description
This antibody is predicted to react with bovine, canine, chicken, human, mouse and non-human primate based on 100% sequence homology. This antibody is specific for the ~74 kDa Raf-1 protein phosphorylated at Ser642.
Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.Chemical Identifiers
| Phospho-c-Raf (Ser642) | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Polyclonal | |
| Liquid | |
| IgG | |
| Human, Rat | |
| Raf1 | |
| 6430402F14Rik; AA990557; BB129353; CMD1NN; CRAF; C-RAF; C-Raf proto-oncogene, serine/threonine kinase; Craf1; Craf1 transforming; D830050J10Rik; EC 2.7.11.1; kinase Raf1; murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV); murine sarcoma 3611 oncogene 1; NS5; Oncogene RAF1; OTTHUMP00000207813; OTTHUMP00000209389; proto-oncogene c-RAF; RAF; raf proto-oncogene serine/threonine protein kinase; RAF proto-oncogene serine/threonine-protein kinase; RAF1; Raf-1; Raf-1 proto-oncogene, serine/threonine kinase; sarcoma 3611 oncogene; v-Raf; v-raf-1 leukemia viral oncogene 1; vraf1 murine le; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1; v-raf-leukemia viral oncogene 1 | |
| Raf1 | |
| Primary | |
| Affinity chromatography |
| 0.25 mg/mL | |
| Western Blot | |
| Unconjugated | |
| Rabbit | |
| RUO | |
| 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5 | |
| P04049, P11345 | |
| 24703, 5894 | |
| Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser642 of rat RAF1 conjugated to KLH. | |
| Antibody |
Specifications
| Phospho-c-Raf (Ser642) | |
| Polyclonal | |
| Unconjugated | |
| Raf1 | |
| 6430402F14Rik; AA990557; BB129353; CMD1NN; CRAF; C-RAF; C-Raf proto-oncogene, serine/threonine kinase; Craf1; Craf1 transforming; D830050J10Rik; EC 2.7.11.1; kinase Raf1; murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV); murine sarcoma 3611 oncogene 1; NS5; Oncogene RAF1; OTTHUMP00000207813; OTTHUMP00000209389; proto-oncogene c-RAF; RAF; raf proto-oncogene serine/threonine protein kinase; RAF proto-oncogene serine/threonine-protein kinase; RAF1; Raf-1; Raf-1 proto-oncogene, serine/threonine kinase; sarcoma 3611 oncogene; v-Raf; v-raf-1 leukemia viral oncogene 1; vraf1 murine le; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1; v-raf-leukemia viral oncogene 1 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 24703, 5894 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Western Blot | |
| 0.25 mg/mL | |
| 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5 | |
| P04049, P11345 | |
| Raf1 | |
| Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser642 of rat RAF1 conjugated to KLH. | |
| 100 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG |