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Invitrogen™ Phospho-ANKRD28 (Ser1007) Polyclonal Antibody
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Catalog No. PIPA5105964
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PIPA5105964 100 μL
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Catalog No. PIPA5105964 Supplier Invitrogen™ Supplier No. PA5105964
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of ANKRD28 only when phosphorylated at Ser1007.

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. ANKRD28 selectively regulated phosphorylation of hnRNP-K at ser284, an effect that was enhanced in vivo by an S1013A/S1017A double mutant, suggesting that ANKRD28 targets PP1 in a regulated manner to dephosphorylate hnRNP-K selectively at ser284.

Specifications

Antigen Phospho-ANKRD28 (Ser1007)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ANKRD28
Gene Accession No. O15084, Q505D1
Gene Alias AI465466; AI604979; ANKRD28; ankyrin repeat domain 28; ankyrin repeat domain-containing protein 28; E430019N21Rik; KIAA0379; mKIAA0379; phosphatase interactor targeting K protein; phosphatase interactor targeting protein hnRNP K; PITK; PP6-ARS-A; PPP1R65; protein phosphatase 1, regulatory subunit 65; protein phosphatase 6 ankyrin repeat subunit A; RGD1559931; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A; serine/threonine-protein phosphatase 6 regulatory subunit ARS-A
Gene Symbols ANKRD28
Host Species Rabbit
Immunogen A synthesized peptide derived from human ANKRD28(Accession O15084), corresponding to amino acid residues around phosphorylated Ser1007.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 105522, 23243
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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