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Invitrogen™ Phospho-53BP1 (Ser1778) Polyclonal Antibody
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Catalog No. pipa5101037
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100 μL
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Catalog No. Quantity
PIPA5101037 100 μL
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Catalog No. PIPA5101037 Supplier Invitrogen™ Supplier No. PA5101037
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of 53BP1 only when phosphorylated at Ser1778.

53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.

Specifications

Antigen Phospho-53BP1 (Ser1778)
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TP53BP1
Gene Accession No. P70399, Q12888
Gene Alias 53BP1; FLJ41424; m53BP1; MGC138366; murine p53-binding protein; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding protein 1; transformation related protein 53 binding-protein 1; Trp53bp1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1
Gene Symbols TP53BP1, Trp53bp1
Host Species Rabbit
Immunogen A synthesized peptide derived from human TP53BP1(Accession Q12888), corresponding to amino acid residues around phosphorylated Ser1778.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27223, 296099, 7158
Target Species Human, Mouse, Rat, Monkey
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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