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Invitrogen™ Phl p 1 Chimeric Recombinant Human Monoclonal Antibody (Clone 25)
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Catalog No. MA551651
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50 μg
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MA551651 50 μg
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Catalog No. MA551651 Supplier Invitrogen™ Supplier No. MA551651
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Description

Human Recombinant Monoclonal Antibody

This antibody binds to the Timothy grass allergen Phl p 1 and shows cotss reactivity with natural group 1 allergens from a variety of grass species such as oat, sweet vernal grass, Bermuda grass, rye grass, common reed, Kentucky blue grass, rye, wheat and maize (weak).

Phl p 1 binds to specific receptors on the surface of immune cells called TLR4 (Toll-like receptor 4) and MD-2 (myeloid differentiation factor 2). This binding triggers a signaling cascade that leads to the activation of immune cells and the release of inflammatory mediators, which cause the allergic symptoms. The interaction between Phl p 1 and TLR4-MD-2 complex has been studied extensively and is considered a key event in the development of grass pollen allergy. Understanding the molecular mechanisms involved in this interaction is important for developing new therapeutic strategies to treat or prevent allergic reactions.

Specifications

Antigen Phl p 1 Chimeric
Applications Dot Blot, ELISA, Western Blot
Classification Recombinant Monoclonal
Clone Clone 25
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Alias Group 1 grass pollen allergen; Phleum pratense allergen 1; Timothy grass pollen allergen
Host Species Human
Immunogen Recombinant Phl p 1, a grass pollen allergen.
Purification Method Affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Plant
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgE κ
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