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Gibco™ PeproGMP™ Human IL-6 Recombinant Protein, PeproTech®

Catalog No. p-200151376
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10 μg
1 mg
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Catalog No. Quantity
01672620 10 μg
5000077996 1 mg
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Catalog No. 01672620 Supplier Gibco™ Supplier No. GMP2000610UG
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Description

Recombinant Protein

The IL-6 protein is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. The PeproTech Recombinant Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues. PeproGMP IL-6 cytokine is most often used with PeproGMP SCF, PeproGMP TPO (thrombopoietin) and PeproGMP Flt3-ligand in hematopoietic stem cells (HSCs) cultures. IL-3 may also be used for further synergistic expansion and immune cell maturation. PeproGMP Recombinant Human IL-6 is also commonly used with PeproGMP IL-2 and PeproGMP IL-15 for B cell cultures. Reconstitute using sterile water (i.e., WFI) to a concentration of 0.1-1.0 mg/ml. Additional product information, specifications, handling and reconstitution information are provided on the Certificate of Analysis. All PeproGMP™ products are manufactured using animal-derived component free materials. Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter 1043 Ancillary Materials for Cell, Gene, and Tissue-Engineered Products.

IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.

Specifications

Accession Number P05231
For Use With (Application) Control, Western Blot Control, Bioactivity
Format Lyophilized
Formulation Protein with no preservative
Gene ID (Entrez) 3569
Molecular Weight (g/mol) 20.9 kDa
Name PeproGMP™ Human IL-6
Purification Method Purified
Quantity 10 μg
Storage Requirements -20°C or -80°C if preferred
Regulatory Status GMP
Endotoxin Concentration ≤0.1 EU/μg
Gene Alias B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6
Common Name IL-6
Gene Symbol Il6
Biological Activity Determined by the proliferation of mouse 7 TD1 cells. PeproGMP Recombinant Human IL-6 ha been tested against the WHO standard NIBSC 89/548.
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM
Content And Storage -20°Cor to +80°C if preferred
Activity Determined by the proliferation of mouse 7TD1 cells. PeproGMP Recombinant Human IL-6 has been tested against the WHO standard NIBSC 89/548. Find the International Unit (IU) value <a href='https://www.thermofisher.com/us/en/home/life-science/cell-culture/cell-culture-learning-center/recombinant-protein-information/international-units.html'>here</a>.
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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